CALL FOR PAPERS Proteomic and Metabolomic Approaches to Cell Physiology and Pathophysiology Proteasome inhibition in skeletal muscle cells unmasks metabolic derangements in type 2 diabetes
نویسندگان
چکیده
Lubna Al-Khalili, Thais de Castro Barbosa, Jörgen Östling, Julie Massart, Pablo Garrido Cuesta, Megan E. Osler, Mutsumi Katayama, Ann-Christin Nyström, Jan Oscarsson, and Juleen R. Zierath Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden; AstraZeneca Research and Development, Mölndal, Sweden; and Department of Functional Biology, Physiology Area, University of Oviedo, Oviedo, Spain
منابع مشابه
Proteasome inhibition in skeletal muscle cells unmasks metabolic derangements in type 2 diabetes.
Two-dimensional difference gel electrophoresis (2-D DIGE)-based proteome analysis has revealed intrinsic insulin resistance in myotubes derived from type 2 diabetic patients. Using 2-D DIGE-based proteome analysis, we identified a subset of insulin-resistant proteins involved in protein turnover in skeletal muscle of type 2 diabetic patients, suggesting aberrant regulation of the protein homeos...
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